Leptin & Weight Loss: What You Need to Know

Leptin & Weight Loss: What You Need to Know

Leptin is at the top of the hormonal hierarchy. Leptin & weight loss are very, very closely linked. Leptin might as well lumped in with insulin (in terms of its paramount importance) because, like insulin, its influence on fat loss is overwhelming. Here’s the thing about leptin: it’s JOB is to keep you from storing too much fat. Unfortunately, when it’s signaling ability gets screwed up, it can make it very difficult for you to release and burn fat.

Leptin is released by our fat cells. Consider it the “hall monitor” of fat accumulation. When you start accumulating excess body fat in your adipose tissue, your fat cells release leptin to signal the brain that plenty of fuel is available. This signal then kicks off a cascade of events to decrease your hunger and increase your metabolism (by stimulating your thyroid and adrenals).

On the flip side, when there aren’t an excess of fat cells secreting leptin, the low leptin levels communicate to the brain that there isn’t enough energy stored and so your appetite is stimulated and your metabolic rate is slowed down to help conserve energy.

Sounds like a pretty perfect system that should keep anyone from gaining too much weight, right? Unfortunately, just like what happens with insulin, we fuel our bodies so poorly that leptin’s ability to signal goes very wrong. Just like we have the carbohydrate cycle, there is a similar cycle I’ve put together to show how chronically high carbohydrate diets and high insulin levels impair the proper function of leptin in a big way.

 

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Let’s look at what happens here – and remember – this is what happens over time, leading to excess weight gain, insulin resistance and ultimately leptin resistance, making it hard for overweight and obese people to break the cycle and successfully lose weight.

So you’ll recall that when we routinely eat high carbohydrate diets, especially processed, cheap carbohydrates that send our blood sugar through the roof, our body becomes far less sensitive to the presence of insulin (check out this insulin overview I posted a couple months ago). This is what we call insulin resistance and it causes our body to store more fat. More fat means that more leptin is going to be released (because leptin is released by our fat cells). Well, as you continuously pile on more fat cells, leptin secretion continues to rise. The same thing happens that we saw with insulin. Leptin is always around and your body tunes out the signals it is sending out. Leptin resistance and insulin resistance go hand in hand.

When you are leptin resistant to any degree, your body won’t receive the satiety signals it is supposed to. You can eat in excess without feeling full. Your hunger mechanisms are rarely turned off. Your metabolic rate slows because you aren’t receiving the messages that ample fuel is available (in your fat stores) so your adrenal and thyroid function slows. So you eat more, you are highly likely to store the food you do eat as excess body fat, and you rarely feel satisfied.

There is good news though. As with insulin, we have a tremendous amount of control over the action of leptin through the food we eat and the lifestyle habits we adopt. Because leptin is so significantly impacted by insulin, one of the most important things you can do to encourage healthy leptin signaling is to control blood sugar. How do we do that?

  • Eliminate processed foods
  • Reduce or eliminate wheat and grains
  • Focus on whole foods such as vegetables, fish, beef, poultry, nuts, seeds and some fruits
  • Eat protein and healthy fat at every meal
  • Avoid carbohydrate intake in the morning
  • When you are ready, incorporate high intensity interval workouts 2-3 times each week.
  • Keep your sugar intake low – even natural sugars like honey

These metabolic hormones are all closely intertwined. We’ve talked about how insulin and leptin go hand in hand but you also see that leptin function influences your thyroid hormones and your adrenals. You cannot address one without impacting the other. If you do damage to one, it will impair the others. Remember that while calories do matter, you can’t make lasting progress without working towards balancing these critical metabolic hormones.

The Duct Tape of the Human Body?

The Duct Tape of the Human Body?

Oh boy am I excited to write about this topic. I’m not sure why – it’s not something that has been a lifelong passion for me or anything – but when I started to learn more about it and realized how much of what I thought I knew was wrong, I knew I had to share it with you. I want to talk to you about cholesterol. That word has an unfairly negative connotation. It blows my mind that you can go to reputable sites from health institutions and the government and read so much about cholesterol that just is flat out wrong.

Cholesterol is a fat-like substance that is so critical to human health that every single cell within our bodies is equipped to produce it on its own. Our liver is designed to recycle it so we can get as much use out of it as possible. Cholesterol is used to make vitamin D, to make hormones, and to make neurotransmitters (such as serotonin, a primary regulator of mood). Cholesterol is required for the formation of synapses in your brain – allowing you to think, analyze and store information.

It’s no surprise that human breast milk is naturally high in cholesterol and even contains a special enzyme to make sure that infants absorb as much of it as possible.

Nora Gedgaudas, author of “Primal Body, Primal Mind” refers to cholesterol as the human body’s version of duct tape. I love that and think its spot on. Cholesterol is deployed in response to chronic stress, poor dietary choices, thyroid issues, injury or inflammation. Because of that, it’s often found “at the scene of the crime” in the case of arterial damage.

You see, when there is damage within our bodies, new cells are generated to help repair the damage. Cholesterol is a component of those new cells. In additional to that, cholesterol – that duct tape of the human body – is carried to the scene of the crime via its carrier, LDL, to help patch up the damage. Unfortunately, because of our generally poor dietary choices and chronic stress, we never stop initiating this damage. Chronically high carbohydrate consumption keeps our inflammatory response in overdrive. Chronic stress causes internal damage and our body never gets a break. But cholesterol keeps doing its job – getting deployed out to the scene of the crime to patch things up. Well of course, if you keep slapping on additional layers of duct tape it will pile up and yes, you guessed it, you start to see “clogged arteries”.

Since cholesterol is there, it gets the blame. How about we look at what’s causing the damage!? Cholesterol is a healing substance – why is it chronically needed for healing? Where’s the damage coming from and how do we make THAT stop? It’s like saying that since police are at the scene of every crime we need to focus on reducing the number of police so that there is less crime. Um, yeah, go ahead and try that.

Now, I want to make one more point about cholesterol from food sources. Yes, your body is capable of producing cholesterol on its own. However, it’s a very complex and inefficient process. When you consume cholesterol from food sources, your body is able to down regulate cholesterol production. There is a natural system of checks and balances in place because we were designed to consume cholesterol rich foods like eggs and animal proteins. However, when you dramatically cut cholesterol and saturated fats from your diet, your body sends its cholesterol production into overdrive because it can’t possible survive without ample cholesterol.

If you want to be healthy, if you want your body to function optimally, if you want your immune system to be strong, here’s my advice: eliminate the cause of the damage within your body. Cut out processed foods and wheat products. Focus on whole foods, fruits, vegetables, healthy fats and high quality meat, poultry and seafood. Don’t think you’re doing yourself any favors by cutting your cholesterol intake or limiting your fat intake. The real culprit here is inflammation and the primary drivers of inflammation are poor food choices and chronic stress.